Stimulants are being used with increasing frequency by students across college campuses (see ‘Harvard Students: Reaching for drugs to boost brain power). Many of them, however, probably aren’t well aware of the various side effects. In addition to chronic cognitive problems, amphetamines can also induce catastrophic acute events.

An article in the December 2006 issue of Neurology [Reference here] describes a couple of cases of carotid artery dissections following amphetamine use. The carotid arteries are two of the major blood vessels that travel up the neck and supply blood to the brain. When these arteries dissect (tear), strokes often ensue. A stroke is a focal area of permanent brain death due to lack of blood flow.

Cocaine, another sympathomimetic (drug that mimics the effects of sympathetic nervous system stimulation), has also been reported to cause tears in major blood vessels.

It is also important to note that amphetamines and cocaine can also lead to strokes via another mechanism: inflammation of blood vessels in the brain [click here for reference]. The medical term for this process is Vasculitis.

Since the vast majority of strokes are "silent", I suspect the prevalence of strokes due to stimulants is much higher than officially reported or recognized.

As far as more common chronic side effects, an earlier smartkit post details how just 3 months of Ritalin use (an amphetamine) can significantly damage the very blueprint of cell architecture- DNA.

In future posts, I’ll discuss oxidative damage as well as cardiac side effects.

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One of the main benefits of stimulant drugs (such as cocaine, ephedrine, and amphetamines like Ritalin) is their ability to dramatically increase mental energy and concentration. They can make it easier to focus on your work and studies for prolonged periods of time.

How is this achieved? Basically, it’s thought that psychostimulants increase catecholamine neurotransmission in the brain.

Catecholamines are a special category of brain chemicals used for neurotransmission. They include epinephrine, norepinephrine, and dopamine.

Unfortunately, however, these drugs often have very harmful side effects (both long- and short-term), and taking them can sometimes result in death. What most people don’t realize is that there is a much safer, more natural way to boost brain catecholamines: Acute Bouts of Aerobic Exercise.

Both stimulants and aerobic exercise exert similarly powerful effects on: norepinephrine, dopamine, and epinephrine. There is quite a bit of evidence in the scientific literature to back this up. [see References 1-6 below].

Since it is widely believed that the beneficial effects of stimulants stem from their ability to boost catecholamines in the brain, it certainly makes sense that aerobic exercise would produce these same beneficial effects (dramatic increases in mental energy and concentration). Is there any direct evidence to support the idea that aerobic exercise actually enhances cognition? Absolutely:

• “Acute exercise can improve learning and mental performance.”[Reference 7]

• “Acute bouts of exercise selectively facilitate multiple cognitive processes; exercise can, under certain conditions, enhance response speed and response accuracy, and it can facilitate cognitive processes that are central to problem-solving and goal-oriented action.”[Reference 8]

• “Exercise produces a condition during which individuals are able to perform both simple and complex tasks rapidly and efficiently.”[Reference 8]

• “Acute bouts of exercise improve the ability to block irrelevant information and to select and respond to task-relevant information.”[Reference 9,10] (Note: This is the basis of concentration)

• “Recent studies have provided the research community with clear support for an improvement of cognitive performance during exercise”[Reference 11]

So yes, it’s true. One of the most powerful nonpharmacologic ways to boost your ability to concentrate and focus while studying is to exercise aerobically beforehand.

References: 

1.Winter B, Breitenstein C, Mooren FC. High Impact running improves learning. Neurbiol Learn Mem. Dec 2006.

2.Ransford CP. A role for amines in the antidepressant effect of exercise: a review. Med Sci Sports Exerc. 1982;14(1):1-10.

3.Peyrin L, Pequignot JM, Lacour JR, et al. Relationships between catecholamine or 3-methoxy 4-hydroxy phenylglycol changes and the mental performance under submaximal exercise in man. Psychopharmacology (Berl). 1987;93(2):188-192.

4.Meeusen R, De Meirleir K. Exercise and brain neurotransmission. Sports Med. Sep 1995;20(3):160-188.

5.Pagliari R, Peyrin L. Physical conditioning in rats influences the central and peripheral catecholamine responses to sustained exercise. Eur J Appl Physiol Occup Physiol. 1995;71(1):41-52.

6.Pagliari R, Peyrin L. Norepinephrine release in the rat frontal cortex under treadmill exercise: a study with microdialysis. J Appl Physiol. Jun 1995;78(6):2121-2130.

7.Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. Jun 2002;25(6):295-301.

8.Tomporowski PD. Effects of acute bouts of exercise on cognition. Acta Psychol (Amst). Mar 2003;112(3):297-324.

9.Hogervorst E, Riedel W, Jeukendrup A, et al. Cognitive performance after strenuous physical exercise. Percept Mot Skills. Oct 1996;83(2):479-488.

10.Lichtman S, Poser EG. The effects of exercise on mood and cognitive functioning. J Psychosom Res. 1983;27(1):43-52.

11.Brisswalter J, Collardeau M, Rene A. Effects of acute physical exercise characteristics on cognitive performance. Sports Med. 2002;32(9):555-566.

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A recent Harvard University newspaper article suggests that many Harvard students casually rely on prescription stimulant drugs to get a competitive edge and boost brain power while studying.

The article further suggests that stimulants like Adderall and Ritalin "might be on their way to becoming the new coffee".

I’ve also seen studies that show up to 25-30% of college students in the U.S. are using stimulant drugs to get ahead academically.

Apparently, students are going to health clinics and lying to the doctors there to get their hands on the drugs. They, in turn, pass them out to friends. One student notes: "During exam time, I know I’ve got a steady stream of people who come to me and I don’t turn them away. In my experience I’ve found that if people know it’s available, not a lot is holding them back.

Unfortunately, most students of Generation Rx don’t realize the hidden dangers of amphetamines.

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