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Archive for the ‘Brain’ category

Lately, I’ve been dismayed by the many young patients (35-45) I’ve come across who’ve had heart attacks and strokes. Some have been physician colleagues of mine who eat well and do not drink or smoke.

Since heart attacks and strokes are basically the same thing (tissue dying due to clogged arteries), figured many would find this information helpful:

Earlier medical research has shown that

  • Depression and
  • Hostility

are both associated with heart attacks.

Now, a new study indicates that Chronic Anxiety is an additional important risk factor for heart attacks.

 

Can negative emotions twist, deform, and hurt your body? Perhaps so….

 

Reference: Shen B-J, Avivi YE, Todaro JF, et al. Anxiety characteristics independently and prospectively predict myocardial infarction in men. The unique contribution of anxiety among psychologic factors. J Am Coll Cardiol. 2007;doi:10.1016/j.jacc.2007.09.033

 


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Don’t be shy, just smile!

December 22nd, 2007

A smile combined with a direct gaze can boost your attractiveness to the opposite sex up to eightfold. [Research published in the Royal Society's Proceedings B journal, click here for full article/abstract- from the homepage of Dr. Claire Conway, one of the paper's authors.]

You may also like reading this earlier smartkit post: How falling in love improves your brain

and

Does a broken heart equal a broken brain?

 

 


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MK-ULTRA: code name for a CIA mind-control research program that began in 1950. On the Senate floor in 1977, Senator Ted Kennedy said: "…The Deputy Director of the CIA revealed that over thirty universities and institutions were involved in an ‘extensive testing and experimentation’ program which included covert drug tests on unwitting citizens ‘at all social levels, high and low, native Americans and foreign.’ Several of these tests involved the administration of LSD to ‘unwitting subjects in social situations.’ "[Ref: Wikipedia]

A Washington Post article January 14th, 2007 about "…a community of people who believe the government is beaming voices into their minds. They may be crazy, but the Pentagon has pursued a weapon that can do just that"

A December 10, 2007 article in Advertising Age: "…An A&E Billboard in New York City Whispers’ a Spooky Message Audible Only in Your Head in Push to Promote Its New ‘ParaNormal’ Program….The billboard uses technology manufactured by Holosonic that transmits an "audio spotlight" from a rooftop speaker so that the sound is contained within your cranium".


 


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The Aliens Among Us

December 10th, 2007

Here’s a great article on intelligence that, despite being written more than 25 years ago, is still a fascinating read. The author is Professor Bruce Fleury, an Evolutionary Biologist at Tulane University. [Thanks to Dr. Fleury for permission to repost the article here on smartkit].


While we spin elaborate theories about the nature and distribution of alien intelligence, we generally ignore the presence of intelligent aliens on our own planet, beings which preceded us in evolving a complex brain by over thirty million years.

These terrestrial aliens are the Cetaceans, a large group of marine mammals which includes the whales, dolphins, and porpoises. In several respects, these graceful and curious animals can serve as a useful model for our attempts to communicate with extraterrestrial beings. We are likely to encounter many of the same types of problems in breaking the communication barrier between human and dolphin that we will discover in attempting to communicate with an extraterrestrial intelligence.

The intelligence of the dolphin (Tursiops truncates) still remains a matter of some controversy among researchers, but there can be little doubt that the Cetacean brain has reached a level of evolution matched only by the primates. In every area in which gross neuroanatomy has been correlated with intelligence, the dolphin’s brain is highly developed. Both their brain and ours, for example, have an extremely intricate cerebral cortex. Although the dolphin’s cortex is somewhat thinner, with neurons packed much less densely than our own, its surface is folded and fissured to a much greater extent than the human brain, providing a vast cortical surface area. The associational cortex, or "silent brain", which is responsible for the most basic human qualities, is large in the dolphin in the very same areas in which ours is larger than the apes.

Despite the dolphin’s fundamental biological similarity to ourselves, they have evolved into creatures with whom, at least superficially, we seem to have little in common. The dolphin’s biochemistry and physiology, however, is much like our own. They are air breathers, warm blooded, and bear live young like any other mammal.

The Cetaceans were once land animals who, in some yet unknown geologic past, returned to the sea and adapted to a new set of biological demands. The oceanic environment demanded a streamlining of form for more rapid movement in a denser medium. The bones on the upper and lower limbs gradually fused, evolving into flukes and flippers better suited to the Cetacean’s new mode of existence.

Since the murky ocean depths preclude the heavy reliance many mammals place on the visual cortex in obtaining food, Cetaceans evolved a complex echolocation system, analogous to radar but using sound waves in the water. Sound travels four and one half times faster in water than in air and can travel over much larger distances.

It is entirely possible that this great dependence on sonic echolocation or sonar was the factor that triggered the development of the Cetacean brain. Dolphins are able to make fine sonic discriminations between objects underwater which far exceed the visual acuity of humans. While the dolphin’s sonar evolved primarily as an efficient means of hunting prey, the constant presence in the dark waters of the dolphin’s mortal enemy, the shark, may also have provided an evolutionary incentive for the development of this highly accurate sonar system.

There is a great deal of evidence that these signals have been adapted from food gathering and navigation to communication. Dr. John C. Lilly, the noted delphinologist, has demonstrated the ability of dolphins, isolated from one another in every respect but sonically, to teach simple tasks to one another. The level of vocal exchanges between dolphins in captivity and in the open sea suggests a highly social relationship between individuals, based on their ability to exchange information in the form of trains of sonic impulses.

We usually refer to the coordination of hand and eye, vital for living in trees, in our attempts to explain the explosive evolution of the human brain. In a similar fashion the neural structures required to transmit, receive, and translate the extraordinarily complex acoustical signals generated by the dolphins may have been the spur to their evolution as a non-manipulative intelligence.

This aspect of dolphin evolution leads us to the first problem in the dolphin/alien example. We tend to associate the use of the hand, especially the opposable thumb, with the evolution of an intelligent civilization. This very provincial prejudice pervades our imaginative literature and much of our research efforts. Man, it is repeatedly said, is the measure of all things.

If the dolphin does have, as Dr. Lilly suspects, a sophisticated culture with an oral tradition, we will have to revise our ideas of what constitutes an intelligent civilization. Dolphins erect no permanent structures, use no tools, possess no science (as we understand it), and are so streamlined as to lack the ability to use the facial expressions and body language we rely on in our own society.

Although we are not accustomed to accepting intelligence in a non-human form, who is to say that the dolphin’s water based, acoustically oriented "culture" is not at least as widespread in the universe as our own "manipulatory/visual" one?


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Some highlights from a new study out of Cornell University regarding lead toxicity and the brain:

  • The Center for Disesase Control and Prevention (CDC) has standards that say a lead level below 10 mcg/dl is safe
  • However, 1 out of 10 children in the United States has a blood lead level (BLL) of 5 mcg/dl or higher
  • This new study found that the average IQ scores of children with BLLs of only 5 to 10 mcg/dl were about 5 points lower than the IQ scores of children with BLLs less than 5 mcg/dl.

According to the authors of the six year study:  "The results provide compelling evidence that low-level lead exposure has effects into the school-age years…The bottom line… is that lead is a persistent neurotoxin that causes brain damage. The fact that lead has been found in millions of toys, even toys specifically designed for children to put into their mouths, presents an unacceptable risk. Our findings suggest the need to re-evaluate the current federal standards for lead in consumer products and the current definition of an elevated BLL in children".

 

About a year ago I posted this article about lead effects in adults, that also lists some surprising toxic sources from the home.

 


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New research adds further support to the idea that the higher your education level, the less likely you are to get Alzheimer’s disease and other forms of dementia.

The study found this to be the case even after adjusting for socioeconomic status and other medical diseases. [Education and dementia: what lies behind the association? 2007 Oct 2;69(14):1442-50. Neurology.]

The authors of the study conclude: “Higher educated persons may have a greater cognitive reserve that can postpone the clinical manifestation of dementia.”


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Your brain is extremely fragile, and easily damaged by concussions and other forms of acceleration/deceleration injury. Back in January, I posted the story about Andre Waters-an NFL defensive back who committed suicide at the age of 44. The pathologist who examined his brain concluded it had the appearance of an 85 year old man with Alzheimer’s disease, and thought the severe dementia-like changes were probably due to the multiple concussions sustained over the course of his football career.

The July issue of Neurology Today discusses how the same pathologist (world-renowned Dr. Bennet Omalu, MD out of the University of Pittsburgh) has autopsied the brain of Justin Strzelczyk, a Pittsburgh Steelers lineman who died in a car crash at age 36.

Interestingly, Dr. Omalu finds that Strzelczyk’s brain also has the appearance of an 80 year old man, and shows similar pathologic changes compared to what Andre Waters had in his brain.

This is the 4th football player brain Dr. Omalu has autopsied and diagnosed with chronic traumatic encephalopathy (CTE).

Within several years time, I suspect more and more studies will come forth showing how widespread brain damage is amongst NFL players.

And next up will be the soccer players. Already, well over a dozen studies indicate heading induces measurable cognitive deficits.

Most people are surprised to learn just how fragile and easily damaged the human brain really is.


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Ecstasy damages your brain

A new study, to be published in the journal Human Psychopharmacology: Clinical and Experimental [Authors Keith Laws and Joy Kokkalis from the University of Hertfordshire] shows that the drug ecstasy [MDMA] moderate to markedly damages both short and long-term memory.

The study was a meta-analysis.

Verbal memory appeared to be disproportionately affected compared to visual memory.

Another brand new study, published in the Archives of General Psychiatry, shows that even a first low cumulative dose of Ecstasy is associated with damaged verbal memory ability. [Ref. 1]

According to another recent meta-analysis, Ecstasy use is associated with multiple neurocognitive deficits: [Ref 2]

  • attention/concentration
  • verbal and nonverbal learning and memory
  • psychomotor speed and executive systems

[Reference 1]: Arch Gen Psychiatry. 2007 Jun;64(6):728-36.

[Reference 2]: Psychopharmacology (Berl). 2007 Jan;189(4):531-7.


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Note: The Mindfit software is currently available for purchase in the Smartkit Store here. Below you can read why the founder of the Smartkit website-a fellowship trained, board certified neurologist- decided to offer it for sale in the Smartkit store.

This article presents a review of Mindfit- a new computer program geared to train your brain. Many brain fitness programs have been released over the past year, and I have found this to be one of the most promising. As such, we’ve decided it’d be an appropriate addition to the smartkit store.

In a nutshell, Mindfit is a computerized brain gym designed to be used over an 8-12 month period of time (although you can still practice with the exercises after your training period is over).

It starts with several evaluation sessions, which are used to tailor the computer exercises to your specific abilities. The developers refer to this system as ITS- an Individualized Training System that adapts the difficulty level of the exercises to your abilities and performance as you advance.

After the evaluation session is complete, you train on Mindfit three times per week, 20 minutes a day, for 8 weeks. This process is repeated 3 times for a total of 3 rounds and 72 training sessions.

One important feature of Mindfit is that it continually provides feedback and analyzes your performance as you progress.

Another nice feature of Mindfit is that it tackles multiple cognitive domains. Many people think that by doing crossword puzzles every day (or more recently Sudoku puzzles), they’re doing a great job of exercising their brains. Unfortunately, this is just not true. To best train and sharpen your mind, you need to challenge it with lots of different puzzle types and activities. Novelty and challenge are crucial- otherwise you just won’t get the optimal benefit. Mindfit takes this into account, and features 14 skill areas that it goes to work on. These include:

  • Working Memory
  • Visual Short term memory
  • Auditory short term memory
  • Spatial Perception
  • Planning
  • Location Memory
  • Naming
  • Time estimation
  • Inhibition
  • Divided attention
  • Hand-eye coordination

Is Mindfit for everybody? No. The exercises and overall difficulty level of the programs are mainly geared towards seniors, so I think those who are 50+ will find it most useful. However, because the software adapts to each individuals ability, even those younger can be challenged. Importantly, the developers have done an excellent job in making this software extremely easy to use. I suspect those who’ve never even sat down with a computer before will find it simple to set up and get started.

Over the last several years, quite a bit of research has come out showing that brain training exercises can in fact boost cognitive function (Click here to read about one of the most recent studies that appeared in JAMA, click here to read about a double-blind clinical trial that specifically showed MindFit improved short-term memory, spatial processing and attention/focus). For seniors looking to invest in a computerized brain gym, Mindfit represents a sophisticated piece of software that’s surprisingly easy to use.

Mindfit Demos:

Mindfit Demo #1: "Colored Walls"

Mindfit Demo #2: Picture Match"

MindFit Demo#3: Shape Arrangement"

If you’d like to buy the Mindfit program, click here.

MindFit Hardware Requirements:

A PC system with the following features is needed for ensuring a stable performance:


  • CPU Pentium III 1000 MHz or higher (Software does not currently support Macintosh family of computers)
  • Operating system: Microsoft Windows 2000 SP4 or Windows XP SP2.
  • RAM Memory: 128 MB.
  • CD-Rom Drive.
  • Sound card: PCI 128 bit (speaker or headphones are required)
  • Graphics card: 16MB (support 3D graphics).
  • Screen resolution: 800X600 minimum (16 bit min. or more).
  • Internet connection: Recommended.
  • Internet Explorer: Version 5.5 and up.
  • Free hard disk space:


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Last year I posted about the powerfully negative effects chronic stress has on your memory and brain. Now, a new study [Reference below] published in the June 12, 2007 journal of Neurology provides further evidence this is true by showing:

People who are chronically distressed are 40 percent more likely to develop Mild Cognitive Impairment (MCI) - a precursor to Alzheimer’s disease and other dementia syndromes.

These findings are consistent with dozens of earlier studies showing stress damages the hippocampus- the memory engine of the brain.

A related post relates how stress is sticky, and where in the brain it settles.

[Reference]: Chronic distress and incidence of mild cognitive impairment. R. S. Wilson, J. A. Schneider, P. A. Boyle, S. E. Arnold, Y. Tang, and D. A. Bennett. Neurology 2007 68: 2085-2092


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This important strategy should help improve your learning efficiency and memory. It’s presented in college student context, but of course applies to anyone looking for a good study tip.

Imagine that a psychology lecture has just let out. The vast majority of students will wait several weeks to review their lecture notes. Unfortunately, when they do so, very little of what they’ve written will make sense. The notes will be difficult to follow, and the content hard to understand. They might as well be seeing the material for the first time. Why? The answer is simple: Their memory of the material has long since decayed.

Why does forgetting happen?

Most students incorrectly believe that after learning new information, they steadily forget a little bit each and every day that passes.

This is a myth. Actually, newly learned information has a relatively short half-life in your brain. This fact is demonstrated very nicely by the forgetting curve.

The forgetting curve is not a new phenomenon. German psychologists (e.g., Herman Ebbinghaus) were plotting these curves 150 years ago. Since that time, a great deal of accumulated data has supported their validity. Take a look at the forgetting curve shown here:

 


The peak of the curve (T) represents your memory for material immediately after the learning session—let’s say the end of a lecture. Now, we can conclude 2 things from the curve: The Obvious and the Not-so-Obvious.

The Obvious:

We can see it makes no sense to wait until midterms or final exams to do your first review (that is, to wait until Day 30 or longer on the above graph). By that time, you’ll have forgotten more than 95 percent of the material. You’ll feel as if you’re encountering the information in your notes for the first time, and what should take you only 4 minutes to review will now take you 40 minutes. The notes will look foreign because you won’t remember anything.

Not-so-Obvious:

However, there’s a more important conclusion we can reach from the curve: You don’t have to wait several weeks for this degree of forgetting to occur. Massive forgetting actually happens within hours of the initial learning session. Therefore, even those students who wait several days to review the material are in trouble! If you look carefully at the graph, you can see that even before Day 2 arrives, you will already have forgotten 40–70 percent of what you learned!

The crucial point is this: Make sure to review new material within hours of any initial learning episode.

The vast majority of students could save dozens of hours of study time per semester by using this one technique alone to markedly improve learning efficiency and memory.

Notice how a small investment up front pays huge dividends come exam time.

It is also worth noting that these recommendations apply not only to lectures, but to any academic learning—whether from a textbook, video, or computer learning session.

 


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Researchers in Ireland have found that brain exercises in the form of rote memorization of poems, articles, and short stories leads to memory improvement.

The study was done on healthy adults aged between 55 and 70. They underwent six weeks of intensive brain exercises involving rote memorization of a newspaper articles or poems of 500 words, followed by six weeks of rest.

Interestingly, the improvement was not seen immediately. When the study participants were tested 6 weeks later, however, a clear improvement in verbal and episodic memory was noted.

Furthermore, changes were actually detected in the hippocampus via high tech brain scans called Magnetic Resonance Spectroscopy (MRS).

Dr. Richard Roche, a co-author of the study from the Department of Psychology at National University of Ireland in Maynooth:

The brain is like a muscle that should be exercised through the retirement years as a defense against dementia, cognitive lapses and memory failure

You can read more about the rote memory training study here. For an earlier smartkit article that discusses how brain training exercises can improve memory and cognitive function, click here.

For computer software that can enhance cognitive function, check out this review of  Mindfit  

[Reference: McNulty, J,. Paul Brennan, M.D., Colin P. Doherty, M.D., D. McMackin, M.D., S. Sukumaran, M.D., I.H. Robertson, Ph.D., M.A. Mangaoang, Ph.D., S.M. O'Mara, D.Phil., Sinead L. Mullally, Ph.D., J. Hayden, B.A., J. Prendergast, B.Sc., and M. Fitzsimons, Ph.D.. The Identification of Neurometabolic Sequelae Post-learning Using Proton Magnetic Resonance Spectroscopy. Presented November 26 at the annual meeting of the Radiological Society of North America (RSNA)]

 


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[click on image above to jump to journal article detailing brain-heart interactions]

According to a just released report in Japan by the Ministry of Health, Welfare, and Labor, nearly 150 people lost their lives in 2006 to Karoshi.

Karoshi is a Japanese term for "death from overwork".

Back in the 1980s, when several high-ranking business executives who were still in their prime years suddenly died without any previous sign of illness, the media began picking up on what appeared to be a new phenomenon. This new phenomenon was quickly labeled kar?shi. [Wikipedia]

According to this article:

Because of peer pressure to keep up with co-workers, out-do competing groups and increase market-share at the expense of competitors, hundreds of thousand of Japanese managers are caught up in a vortex of psychological pressure that forces them to work at a frenzied pace.

Is this possible? Can you suddenly die from overworking? Absolutely. Severe stress can in fact trigger cardiac arrhythmias, heart attacks, and strokes. Over the years, many of the younger stroke patients I’ve consulted on in the hospital give a history of severe stress in the days leading up the stroke.

In the last decade we’ve learned that strong emotions and stress activate specific brain regions which in turn directly influence cardiac rate and rhythm via the autonomic nervous system. A very nice review of this topic (full text & free PDF) can be found here. It’s entitled: Brain-Heart Interactions. The neurocardiology of arrhythmia and sudden cardiac death. A diagram from the article illustrating the anatomic brain-heart connections is shown above.

We therefore have a mechanism by which ethereal emotions can have a concrete, injurious effect on heart tissue.

Unfortunately, as this world gets increasingly competitive, more and more people are getting desperate and having to work harder and harder to achieve success. Thus we have up to 25% of college students using stimulants, and are starting to see the 70-hour work week become the new standard.

Reference for above Brain-Heart article: Tex Heart Inst J. 1993; 20(3): 158–169.

 


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From a recent update posted on the Medscape Neurology section:

Researchers at the American Academy of Neurology 59th Annual Meeting presented preliminary results from a study showing that long term exposure to secondhand smoke alone increases your risk for dementia by about 30%.

If you’re interested in learning more about the potential mechansim by which cigarattes destroy your brain, click here to read this earlier post. 

 

Reference: American
Academy of Neurology 59th Annual Meeting: Abstract S01.005. April 28 – May
5, 2007.


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